Clinical outcomes of prolonged infusion (extended infusion or continuous infusion) versus intermittent bolus of meropenem in severe infection: A meta-analysis.

BACKGROUND:Meropenem exhibits time-dependent antimicrobial activity and prolonged infusion (PI) (extended infusion or continuous infusion, EI or CI) of meropenem can better achieve pharmacodynamics target when comparing with intermittent bolus (IB).However, the clinical outcomes between two groups remain inconclusive.OBJECTIVE:To evaluate current p

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Dynamic Characteristics and Chloride Resistance of Basalt and Polypropylene Fibers Reinforced Recycled Aggregate Concrete

Fiber polymer has been extensively used to improve the mechanical properties and durability of concrete.However, the studies of the effect of fiber polymer on the dynamic performance of recycled aggregate concrete Monopod (RAC) is still very limited.In this study, we prepared two types of RAC formulations: RAC reinforced with basalt fibers (BFs) an

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Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions.

While much is known about acute infection pathogenesis, the understanding of chronic infections has lagged.Here we sought to identify the genes and functions that mediate fitness of the pathogen Pseudomonas aeruginosa in chronic wound infections, and to better understand the selective environment in wounds.We found that clinical isolates from chron

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